West, 43, is running as a candidate for his self-styled “Birthday Party”.
At the event, the rapper seemed to make policy decisions off-the-cuff and made several rants, including on abortion and on abolitionist Harriet Tubman.
Fans have questioned whether his last-minute bid for the White House is actually a promotional stunt.
The Charleston rally did little to clarify whether his run is genuine. But a now-deleted tweet sent from West’s account on Saturday, appearing to show the song list for a new album, added to the speculation.
The event, held at a wedding and conference hall in the city, was said to be open to registered guests only – but West’s campaign website had no function for people to register or RSVP.
West appeared with “2020” shaved into the back of his head and wearing a protective security vest, and addressed the gathered crowd without a microphone.
There were no audience microphones either, leading West to repeatedly tell the crowd to be silent so he could hear the questions being asked.