Madrid became the first team in the Champions League era to successfully defend the trophy with their sixth triumph in the competition – and 12th when you include it in its former guise of the European Cup – three of those victories coming in the last four years.
A thrilling first half saw Ronaldo put Madrid ahead, becoming the first player to score in three different Champions League finals in the process.
Mario Mandzukic equalised for Juventus with a spectacular overhead kick that will live long in the memory.
But Madrid dominated the second half as Juve collapsed, Casemiro scoring with the help of a huge deflection before Ronaldo made sure of the victory from close-range, ensuring he finishes above Lionel Messi as the competition’s top scorer in the process.
Any hopes of a Juventus comeback were ended when substitute Juan Cuadrado was sent off 18 minutes after coming on, the winger receiving a second yellow for a clash with Sergio Ramos, before Madrid substitute Marco Asensio put the icing on the cake in the last minute.
Having also secured LaLiga glory, the win seals a famous double for Zinedine Zidane in his first full season at the helm, with Madrid the first side since AC Milan in 1990 to win back-to-back European crowns.
Juventus, who had been seeking a treble after winning Serie A and the Coppa Italia, have now lost five straight finals since last tasting continental success back in 1996, including two of the last three, having also lost to Barcelona in Berlin two years ago.
Former Madrid star Gonzalo Higuain tested Keylor Navas early on with a 25-yard drive, before the goalkeeper had to make a terrific one-handed save to keep out a powerful Miralem Pjanic strike from a similar distance.
It was Madrid, though, who opened the scoring after 20 minutes, Ronaldo capping a slick passing move.
Karim Benzema and Ronaldo were both involved in the build-up before Dani Carvajal’s cut-back led to the Portugal international producing an impressive first-time finish, finding the far corner from the edge of the area with the help of a slight deflection off Leonardo Bonucci.
The lead lasted just seven minutes before Juve hit back in magnificent fashion.
Bonucci’s pass from defence was helped on by both Alex Sandro and Higuain – the ball not leaving the ground throughout – to set up Mandzukic and the Croatia international took one touch and unleashed a magnificent overhead kick into the top corner, with Navas not close to it.
The Italian champions needed a superb intervention from Bonucci to stop Bale from tapping in a Ronaldo cross, before coming close themselves when Alex Sandro’s glancing header fell just wide from Dani Alves’ free-kick.
A miserable night for Juve got worse with six minutes to go when Cuadrado, already booked for a late challenge on Ronaldo, saw red after Ramos went down dramatically, the Colombia international having lightly pushed him and made minimal contact with his foot.
Madrid wrapped up a famous triumph in the final minute when Asensio – eight minutes after coming on – slotted in left-footed from eight yards after superb work from Marcelo down the left in an emphatic triumph for Zidane.